Scientists have created a coronavirus-winning antibody
European scientists have managed to create an antibody that can defeat coronavirus in the laboratory. This is an important step in finding a cure for the disease and trying to stop the spread of the epidemic.
Scientists have created a monoclonal antibody that was able to defeat the coronavirus in the laboratory. This is stated in a study published in the peer-reviewed journal Nature Communications.
The study was conducted at the University of Utrecht by scientists from the Netherlands and Germany under the guidance of Professor Berend-Jan Bosch. Monoclonal antibodies are laboratory-created proteins similar to those produced by human immune cells. They recognize a specific pathogen site and act on it.
Although the new discovery cannot yet be used in drug development, since the antibody needs to be tested in animals and humans first, development can help prevent infection or treat infected COVID-19 and coronavirus-related diseases in the future, Bloomberg notes.
An antibody known as 47D11 acts on a pointed protein in the shape of a corona, by which the SARS-CoV-2 virus penetrates human cells. As the study progressed, 47D11 not only defeated COVID-19, but also its “cousin,” the virus that causes acute respiratory syndrome (SARS), which also has similar protein spikes.
Scientists used genetically modified mice to produce various antibodies to the pointed protein COVID-19, and as a result of screening it turned out that the 47D11 antibody was neutralizing. Researchers then reformatted this antibody to create a version for humans.
Additional studies will be required to find out if the results are confirmed during clinical trials, and how exactly the antibody infects the virus, the study authors note.
Monoclonal antibodies are already successfully used in the treatment of cancer - pharmaceutical giants such as Merck & Co. use them in their preparations. and Roche Holding AG.